Atherosclerotic Carotid Plaque Composition and Incident Stroke and Coronary Events
نویسندگان
چکیده
Increasing evidence suggests that atherosclerotic plaque composition rather than size is linked to ischemic cardiovascular events, yet largescale population-based data in asymptomatic individuals remain scarce. This study sought investigate carotid relation incident stroke and coronary heart disease (CHD) a setting. Between 2007 2012, 1,349 persons (mean age 72 years, 49.5% women) from the Rotterdam Study who were free history of or CHD, whom ultrasonography showed subclinical atherosclerosis, underwent high-resolution magnetic resonance imaging arteries assess characteristics. These included presence specific components (intraplaque hemorrhage [IPH], lipid-rich necrotic core, calcification), measures (maximum thickness stenosis more 30%). Individuals continuously followed for occurrence CHD until January 1, 2015. The authors used Cox regression models association characteristics with incidence adjustments age, sex, risk factors. During median 5.1 years’ follow-up 4.8 years 51 had 83 developed CHD. Independent maximum factors, IPH was associated (fully adjusted hazard ratio: 2.42 [95% confidence interval: 1.30 4.50], 1.95 1.20 3.14]). Presence core calcification not an independent factor findings indicate promise as marker vulnerability healthy atherosclerosis.
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2021
ISSN: ['1558-3597', '0735-1097']
DOI: https://doi.org/10.1016/j.jacc.2021.01.038